Intrauterine growth restriction and genetic predisposition to thrombophilia.
作者： P. Bucciarelli , P. Antonazzo , E. Biguzzi , Tullia Todros , Simona Cardaropoli
DOI: 10.3324/%X
关键词:
摘要: BACKGROUND AND OBJECTIVES: Intrauterine growth restriction is an important cause of morbidity and mortality. Its pathogenesis still a matter debate. The aim this study was to evaluate the association between intrauterine (diagnosed in utero by serial ultrasound examinations characterized abnormal umbilical arterial Doppler velocimetry) thrombophilic polymorphisms (factor V Leiden, prothrombin G20210A) or methylenetetrahydrofolate reductase C677T carried mothers and/or neonates. DESIGN METHODS: This case-control with prospective enrollment. Fetuses were included if they had three characteristics: 1) reduced (measured ultrasound); 2) birth weight below 10th percentile; 3) velocimetry artery. evaluated 48 cases 98 controls polymerase chain reaction (PCR) analysis. RESULTS: Factor Leiden present 2/48 (4%) neonates among 7/98 (7%) controls. Prothrombin G20210A 0/48 (0%) 4/98 Methylenetetrahydrofolate 16/48 (33%) 22/98 (22%) Overall prevalence 18/48 (37%) 33/98 (34%) INTERPRETATION CONCLUSIONS: No found blood flow C677T.
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