摘要: Not too long ago, it was still a mystery how the immune system able to recognize infinite number of viruses, bacteria, and other parasites foreign elements. It thought that antigens served as template around which antibodies molded themselves gain complementary form. In 1955, Niels K. Jerne first suggest response selective rather than instructive, i e , has capacity synthesize billions different encountering antigen only increases production antibody makes best fit. Soon afterwards, Macfarlane Burnet David Talmage suggested each lymphocyte bears one particular receptor that, after encounter with antigen, divides start mass relevant antibody. Later, Susumu Tonegawa elucidated molecular mechanism generates enormous diversity antibodies, discovery genes coding for T cell (TCR) by Tak W. Mak revealed TCR is generated in similar way.
springer.com
sci-hub.st 参考文章(124)
David A. Ferrick, Mark D. Schrenzel, Thera Mulvania, Beryl Hsieh, Walter G. Ferlin, Heather Lepper, Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo Nature. ,vol. 373, pp. 255- 257 ,(1995) , 10.1038/373255A0
M Jutel, W J Pichler, D Skrbic, C Dahinden, A Urwyler, U R Müller, Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. Journal of Immunology. ,vol. 154, pp. 4187- 4194 ,(1995)
L Racioppi, F Ronchese, L A Matis, R N Germain, Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. Journal of Experimental Medicine. ,vol. 177, pp. 1047- 1060 ,(1993) , 10.1084/JEM.177.4.1047
D. Pardoll, Releasing the brakes on antitumor immune response. Science. ,vol. 271, pp. 1691- 1691 ,(1996) , 10.1126/SCIENCE.271.5256.1691
I.A. Fremont, D.H., Matsumura, M., Stura, E.A., Peterson, P.A. & Wilson, Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. Science. ,vol. 257, pp. 919- 927 ,(1994) , 10.1126/SCIENCE.1323877
Ellen S. Vitetta, Philip E. Thorpe, Jonathan W. Uhr, Immunotoxins: magic bullets or misguided missiles? Immunology Today. ,vol. 14, pp. 252- 259 ,(1993) , 10.1016/0167-5699(93)90041-I
D. E. Smilek, D. C. Wraith, S. Hodgkinson, S. Dwivedy, L. Steinman, H. O. McDevitt, A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 9633- 9637 ,(1991) , 10.1073/PNAS.88.21.9633
Tim R. Mosmann, Subash Sad, The expanding universe of T-cell subsets: Th1, Th2 and more Immunology Today. ,vol. 17, pp. 138- 146 ,(1996) , 10.1016/0167-5699(96)80606-2
Sarita Benchimol, Abraham Fuks, Serge Jothy, Nicole Beauchemin, Kinji Shirota, Clifford P. Stanners, Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell. ,vol. 57, pp. 327- 334 ,(1989) , 10.1016/0092-8674(89)90970-7
Lieping Chen, Stephanie Ashe, William A. Brady, Ingegerd Hellström, Karl Erik Hellström, Jeffrey A. Ledbetter, Patrick McGowan, Peter S. Linsley, Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4 Cell. ,vol. 71, pp. 1093- 1102 ,(1992) , 10.1016/S0092-8674(05)80059-5