The 3' untranslated region of the chicken c-src protooncogene modulates gene expression.
作者： Plachý J , Hejnar J , Dezélée P , Calothy G , Trejbalová K
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摘要: Tight regulation of the Src tyrosine kinase activity is essential for a variety cellular processes, namely transitions cell cycle. The peaks are dependent on its posttranslational modifications as well gene expression. 3'UTRs mRNAs often crucial rapid changes protein level. chicken c-src 3'UTR effects expression have been explored. decreased in vivo tumorigenic potential src-activated mutants chickens. This corresponds with finding that reduced and src mRNA levels luciferase vitro. Our results suggest plays role negative control expression, either transcriptionally or posttranscriptionally.
参考文章(39)
Hearn Jay Cho, Kenji Takabayashi, Pei-Ming Cheng, Minh-Duc Nguyen, Maripat Corr, Stephen Tuck, Eyal Raz, Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism Nature Biotechnology. ,vol. 18, pp. 509- 514 ,(2000) , 10.1038/75365
Rosalyn B. Irby, Weiguang Mao, Domenico Coppola, Jimmy Kang, Jean Marc Loubeau, Walter Trudeau, Richard Karl, Donald J. Fujita, Richard Jove, Timothy J. Yeatman, Activating SRC mutation in a subset of advanced human colon cancers Nature Genetics. ,vol. 21, pp. 187- 190 ,(1999) , 10.1038/5971
Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. Journal of the National Cancer Institute. ,vol. 72, pp. 955- 962 ,(1984) , 10.1093/JNCI/72.4.955
J Geryk, P Dezélée, J V Barnier, J Svoboda, J Nehyba, I Karakoz, A V Rynditch, B A Yatsula, G Calothy, Transduction of the cellular src gene and 3' adjacent sequences in avian sarcoma virus PR2257. Journal of Virology. ,vol. 63, pp. 481- 492 ,(1989) , 10.1128/JVI.63.2.481-492.1989
J. Hejnar, P. Hajkova, J. Plachy, D. Elleder, V. Stepanets, J. Svoboda, CpG island protects Rous sarcoma virus-derived vectors integrated into nonpermissive cells from DNA methylation and transcriptional suppression Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 565- 569 ,(2001) , 10.1073/PNAS.98.2.565
F. B. Gao, C. C. Carson, T. Levine, J. D. Keene, Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 11207- 11211 ,(1994) , 10.1073/PNAS.91.23.11207
Shawn Ritchie, F.Mark Boyd, Jason Wong, Keith Bonham, Transcription of the human c-Src promoter is dependent on Sp1, a novel pyrimidine binding factor SPy, and can be inhibited by triplex-forming oligonucleotides. Journal of Biological Chemistry. ,vol. 275, pp. 847- 854 ,(2000) , 10.1074/JBC.275.2.847
P. Martin, C. Henry, F. Denhez, P. Amouyel, C. Bechade, G. Calothy, B. Debuire, D. Stehelin, S. Saule, Characterization of a MH2 mutant lacking the v-myc oncogene Virology. ,vol. 153, pp. 272- 279 ,(1986) , 10.1016/0042-6822(86)90030-9
D. Caput, B. Beutler, K. Hartog, R. Thayer, S. Brown-Shimer, A. Cerami, Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 1670- 1674 ,(1986) , 10.1073/PNAS.83.6.1670
Rosalyn B Irby, Timothy J Yeatman, Role of Src expression and activation in human cancer Oncogene. ,vol. 19, pp. 5636- 5642 ,(2000) , 10.1038/SJ.ONC.1203912