Pharmacokinetics of dihydroartemisinin in Artekin tablets for single and repeated dosing in Chinese healthy volunteers

摘要: Aim. To study the pharmacokinetics of dihydroartemisinin (DHA) in Artekin (compound dihydroartemisinin) tablets Chinese healthy volunteers. Methods. Eighteen volunteers (9 males, 9 females) received for oral administration. The plasma samples DHA were analysed by liquid-liquid extraction and determined HPLC/ESI/MS. Results. concentration-time curves single dose repeated doses fitted to a two-compartment open model. mean pharmacokinetic parameters were: t(1/2(beta))=1.245 +/- 0.495 h, C(max)=243.6 56.15 microg/l, AUC(0 --> infinity)=450 69 h x V(d)=5.75 2.2 l/kg Cl=3.245 0.38 l/h/kg, while they t(1/2(beta))=1.085 0.298 infinity)=444.35 80.43 ng/ml, V(d)=4.62 1.128 ml/kg, Cl=3.0125 0.875 ml/h/kg, respectively. Conclusion. showed that was rapidly absorbed, distributed eliminated subjects. properties not affected gender dose. While accumulation did appear after doses.