Transduction of binding affinity by B lymphocytes: A new dimension in immunological regulation

摘要: To date, immunologists have operated with two primary paradigms governing the antibody response: (1) that affinity maturation is primarily dependent upon antigen-driven selection of both germline and somatically amended repertoires, (2) effector function isotypically determined. The teleost model now suggests these classical should be broadened to incorporate ability B cell transduce strength antigen recognition (affinity) into structural modifications its product, which, in turn, modulates antibody's function. Although this relationship, thus far, has only been examined demonstrated teleost, we find a number individual elements structural/functional relationship reported for mammalian IgM, which prompts future investigations universality. In sum, findings suggest heretofore unrecognized feature lymphocyte discrimination, transduces functionally modified antibodies.