Compounds and methods for ido and tdo modulation, and indications therefor

作者: Wayne Spevak , Guoxian Wu , Jiazhong Zhang , John Buell , Phuongly Pham

DOI:

关键词:

摘要: Disclosed are compounds of Formula I(a): or a pharmaceutically acceptable salt, solvate, tautomer, an isomer deuterated analog thereof, wherein R 4 , 5 6 7 G 1 2 and Ring A as described in any the embodiments this disclosure; compositions thereof; uses thereof.

参考文章(127)
Dean R. Artis, Hanna Cho, Rebecca L. Zuckerman, Bruce England, Prabha L. Ibrahim, Chao Zhang, Sam Gillette, Pde4b inhibitors and uses therefor ,(2005)
Dean R. Artis, Wayne Spevak, Prabha N. Ibrahim, Ryan Bremer, Guoxian Wu, Rebecca Zuckerman, Hongyao Zhu, Jiazhong Zhang, Chao Zhang, Clarence R. Hurt, Compounds modulating c-kit and c-fms activity and uses therefor ,(2006)
Jesse A. May, Bryon S. Severns, Hwang-Hsing Chen, Pyranoindazoles and their use for the treatment of glaucoma ,(2002)
Firoz Jaipuri, Mario Mautino, Jesse Waldo, Sanjeev Kumar, Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization ,(2014)
Gerard McGeehan, Colin M. Tice, Salvacion Cacatian, Alexey V. Ishchenko, Zhenrong Xu, John J. Baldwin, Jing Yuan, Robert D. Simpson, David A. Claremon, Lawrence W. Dillard, Suresh B. Singh, Wei Zhao, Piperidine and morpholine renin inhibitors ,(2007)
Zhenrong Xu, Patrick T. Flaherty, John J. Baldwin, Jing Yuan, David A. Claremon, Lawrence W. Dillard, Jean-Pierre Wery, Suresh B. Singh, Wei Zhao, Robert D. Simpson, Gerard McGeehan, Colin M. Tice, Salvacion Cacatian, Alexey V. Ishchenko, Diaminoalkane Aspartic Protease Inhibitors ,(2005)
Bernard Hoop, James A. Burton, Method and apparatus for ligand detection ,(1983)
Michael V. Milburn, Klaus-Peter Hirth, Methods for the design of molecular scaffolds and ligands ,(2003)