A Feasibility Study of Transdermal Buprenorphine Versus Transdermal Fentanyl in the Long-Term Management of Persistent Non-Cancer Pain

摘要: Objective Buprenorphine and fentanyl transdermal patches are used widely for the management of persistent malignant nonmalignant pain. Buprenorphine patches, both potent opioids, considered to be equally efficacious in managing Various retrospective studies comparing dosage changes buprenorphine pain patients have been completed; however, no long-term prospective, randomized, clinical study has compared effectiveness these patches. The objective present was satisfy this need. Aims This aims compare prospectively efficacy, acceptability, side effects with This would examine feasibility lay groundwork a larger, multicenter where such efficacy safety outcomes two medications can adequately assessed. Design The participants were 46 adults (range 22–80 years.) (mean = 11 years), predominantly lower back Data obtained monthly 12 months. Participants recruited opioid-naive patients, having greater part day night, appropriate treatment After initial assessment, randomly allocated either or patch treatment. then titrated optimal doses medication. Patients adverse unsatisfactory relief treated alternatively discontinued from study. Results Nearly one-third all 41% (8 22) (TDB) group 37.5% 24) (TDF) stopped due unacceptable inadequate relief. remaining showed similar trend improvement intensity, physical activity, sleep, mood throughout study. Significant intensity achieved 6 months stabilized remainder groups. There significant differences over time. However, higher equipotent dose required comparable Compared TDF group, TDB initially experienced relatively less effects. number users suffered local skin reactions. had mood. Thirty-one percent (5 16) 57% 14) needed additional by end 3 By months, 78% (7 9) but comparatively fewer 44% (4 rescue medicines. Both more doctor visits latter half study. Conclusion Thirty total because For those continuing treatment, improvements seen Fifty 43% groups which persisted up Only 11% 13% respectively, sustained after Twenty benefited significantly symptoms depression group. Interestingly, switching seemed increase acceptability preventing tolerance. Confirmation should studied future larger sample.