Transdermal Buprenorphine for the Treatment of Chronic Noncancer Pain in the Oldest Old

摘要: Abstract Context Chronic pain increases with age, and in the elderly, comorbidities polypharmacotherapy make choice of treatment for pharmacological control a complex matter. Objectives We conducted multicenter, prospective, observational study to evaluate efficacy safety buprenorphine transdermal delivery system (TDS) elderly patients chronic noncancer pain. The aim was assess cognitive behavioral status during treatment. Methods included 93 (69 women 24 men); mean age 79.7 years, most cases, due osteoarthritis. Almost three-quarters (74.2%) had suffered more than 12 months. TDS, starting from dose 17.5μg/h. Outcomes were assessed using Mini-Mental State Examination (MMSE), 17-item Hamilton Depression scale (HAM-D 17), Neuropsychiatric Inventory, Barthel Index, Short-Form Health Survey (SF-12), verbal numeric rating scale, Cumulative Illness Rating Scale (CIRS). Results Buprenorphine associated decrease severity without negative effects on central nervous system. On HAM-D there reductions both psychological somatic scores. MMSE, values at beginning end comparable. Evaluation by SF-12 showed improvements physical mental status. CIRS baseline superimposable, indirectly confirming tolerability profile drug. Conclusion Our experience confirms analgesic activity TDS elderly. There an improvement mood partial resumption activities, no influence ability.