Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications.

摘要: Diabetic retinopathy (DR), commonly classified as a microvascular complication of diabetes, is now recognized neurovascular or sensory neuropathy resulting from disruption the unit. Current therapies for DR target vascular disease process, including neovascularization and diabetic macular edema. Since neurodegeneration an early event in pathogenesis DR, it will be important to unravel mechanisms that contribute neuroretinal cell death order develop novel treatments stages DR. In this review we comment on how inflammation, metabolic derangements associated with loss neuroprotective factors, dysregulated glutamate metabolism may retinal during diabetes. Promising potential based these specific aspects pathophysiology are also discussed. Finally, stress importance developing validating new markers visual function can used shorten duration clinical trials accelerate delivery public.