Neurovascular crosstalk between interneurons and capillaries is required for vision

作者: Yoshihiko Usui , Peter D. Westenskow , Toshihide Kurihara , Edith Aguilar , Susumu Sakimoto

DOI: 10.1172/JCI80297

关键词:

摘要: Functional interactions between neurons, vasculature, and glia within neurovascular units are critical for maintenance of the retina other CNS tissues. For example, architecture neurosensory is a highly organized structure with alternating layers neurons blood vessels that match metabolic demand neuronal activity an appropriate supply oxygen perfused blood. Here, using murine genetic models cell ablation strategies, we have demonstrated subset retinal interneurons, amacrine horizontal cells, form capillaries in 2 3 vascular plexuses. Moreover, determined these cells required generating maintaining intraretinal vasculature through precise regulation hypoxia-inducible proangiogenic factors, dysfunction induces alterations to substantial visual deficits. These findings demonstrate specific interneurons interdependent, loss either or both elicits profound effects on photoreceptor survival function.

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