Angiogenesis and Eye Disease.

摘要: The retina consists of organized layers photoreceptors, interneurons, glia, epithelial cells, and endothelial cells. economic model supply demand used to appropriately determine cost is highly applicable the retina, in which extreme metabolic demands phototransduction are met by precisely localized designed vascular networks. Proper development maintenance these networks critical normal visual function; dysregulation characteristic several devastating human diseases, including but not limited age-related macular degeneration diabetic retinopathy. In this article, we focus on lessons learned from study retinal how can be better maintain adult prevent diseases. We then outline vasculotrophic contributions neurons, pigment epithelium (RPE) glia (specifically microglia) before shift our pathology provide molecular contexts for neovascular Finally, conclude with a discussion that applies what have about cells interact vasculature identify validate therapeutic approaches neurovascular disease retina.