Proteoglycans and other repulsive molecules in glial boundaries during development and regeneration of the nervous system.

摘要: Publisher Summary In most systems that have been studied, a common theme is the close association of proteoglycans with glial boundaries. Proteoglycans are complex macromolecules comprised protein core and covalently attached glycosaminoglycan side chains. They major components extracellular matrix in tissues, including nervous system implicated wide variety cellular functions intercellular interactions. The chapter also lists known associated boundaries during development regeneration system. large effective size created by hydration negatively charged glycosaminoglycans, such as chondroitin sulfates could result steric exclusion other molecules from cell surface glycocalyx. This would interfere interaction between adhesion (CAMs) their receptors on growth cone surface. A similar mechanism has proposed for modulation space polysialic acid neural molecule (NCAM). structure presence specific domains glycosaminoglycans open up possibility these carbohydrate sequences may interactions peptide proteins.