Structural reorganization of the dentate gyrus following entorhinal denervation: species differences between rat and mouse.

摘要: Deafferentation of the dentate gyrus by unilateral entorhinal cortex lesion or perforant pathway transection is a classical model to study response central nervous system (CNS) denervation. This has been extensively characterized in rat clarify mechanisms underlying denervation-induced gliosis, transneuronal degeneration denervated neurons, and collateral sprouting surviving axons. As result, candidate molecules have identified which could regulate these changes, but causal link between postlesional changes not yet demonstrated. To this end, mutant mice are currently studied many groups. A tacit assumption that data from can be generalized mouse, fundamental species differences hippocampal architecture fiber systems involved often ignored. In review, we will (1) provide an overview some basics technical aspects denervation model, (2) identify anatomical rats point out their relevance for axonal reorganization process, (3) describe glial local inflammatory (4) consider neurons potential role reactive glia context, (5) summarize two species. Finally, discuss use mice.