Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep.

作者: Christine Culpepper , Stephanie R. Wesolowski , Joshua Benjamin , Jennifer L. Bruce , Laura D. Brown

DOI: 10.1152/AJPREGU.00037.2016

关键词:

摘要: Hepatic glucose production (HGP) normally begins just prior to birth. Prolonged fetal hypoglycemia, intrauterine growth restriction, and acute hypoxemia produce an early activation of HGP. To...

参考文章(53)
R. B. Wilkening, G. Meschia, Fetal oxygen uptake, oxygenation, and acid-base balance as a function of uterine blood flow American Journal of Physiology-heart and Circulatory Physiology. ,vol. 244, ,(1983) , 10.1152/AJPHEART.1983.244.6.H749
Jason Gien, Nancy Tseng, Gregory Seedorf, Gates Roe, Steven H. Abman, Endothelin-1 impairs angiogenesis in vitro through Rho-kinase activation after chronic intrauterine pulmonary hypertension in fetal sheep Pediatric Research. ,vol. 73, pp. 252- 262 ,(2013) , 10.1038/PR.2012.177
Anne M. Maliszewski, Monika M. Gadhia, Meghan C. O'Meara, Stephanie R. Thorn, Paul J. Rozance, Laura D. Brown, Prolonged infusion of amino acids increases leucine oxidation in fetal sheep. American Journal of Physiology-endocrinology and Metabolism. ,vol. 302, ,(2012) , 10.1152/AJPENDO.00026.2012
Colin D Rudolph, Christine Roman, Abraham M Rudolph, Effect of acute umbilical cord compression on hepatic carbohydrate metabolism in the fetal lamb. Pediatric Research. ,vol. 25, pp. 228- 233 ,(1989) , 10.1203/00006450-198903000-00002
Albert C. Koong, Elizabeth A. Auger, Eunice Y. Chen, Amato J. Giaccia, The Regulation of GRP78 and Messenger RNA Levels by Hypoxia Is Modulated by Protein Kinase C Activators and Inhibitors Radiation Research. ,vol. 138, ,(1994) , 10.2307/3578763
Paul J Rozance, Sean W Limesand, James S Barry, Laura D Brown, William W Hay, Glucose Replacement to Euglycemia Causes Hypoxia, Acidosis, and Decreased Insulin Secretion in Fetal Sheep With Intrauterine Growth Restriction Pediatric Research. ,vol. 65, pp. 72- 78 ,(2009) , 10.1203/PDR.0B013E318189358C
Jerzy Stanek, Comparison of placental pathology in preterm, late-preterm, near-term, and term births. American Journal of Obstetrics and Gynecology. ,vol. 210, pp. 2- 4 ,(2014) , 10.1016/J.AJOG.2013.10.015
Stephanie R. Thorn, Timothy R. H. Regnault, Laura D. Brown, Paul J. Rozance, Jane Keng, Michael Roper, Randall B. Wilkening, William W. Hay, Jacob E. Friedman, Intrauterine Growth Restriction Increases Fetal Hepatic Gluconeogenic Capacity and Reduces Messenger Ribonucleic Acid Translation Initiation and Nutrient Sensing in Fetal Liver and Skeletal Muscle Endocrinology. ,vol. 150, pp. 3021- 3030 ,(2009) , 10.1210/EN.2008-1789
Robert H Lane, Annette S Flozak, Edward S Ogata, Graeme I Bell, Rebecca A Simmons, Altered hepatic gene expression of enzymes involved in energy metabolism in the growth-retarded fetal rat. Pediatric Research. ,vol. 39, pp. 390- 394 ,(1996) , 10.1203/00006450-199603000-00003
Kari A. Teramo, Obstetric problems in diabetic pregnancy – The role of fetal hypoxia Best Practice & Research Clinical Endocrinology & Metabolism. ,vol. 24, pp. 663- 671 ,(2010) , 10.1016/J.BEEM.2010.05.005