EFFECTS OF FASTING ON DISEASE ACTIVITY, NEUTROPHIL FUNCTION, FATTY ACID COMPOSITION, AND LEUKOTRIENE BIOSYNTHESIS IN PATIENTS WITH RHEUMATOID ARTHRITIS
作者： Ingiäld Hafström , Bo Ringertz , Hans Gyllenhammar , Jan Palmblad , Mats Harms-Ringdahl
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摘要: Fourteen patients with rheumatoid arthritis (RA) were studied before, during, and after a 1-week total fast. Disease activity decreased, as did the neutrophil release of lysozyme induced by ionophore A23187. The ability zymosan-activated RA patient serum to aggregate control neutrophils was reduced, together concentrations C3. relative contents arachidonic acid eicosapentaenoic increased in serum, platelets, neutrophils, whereas levels linoleic linolenic unchanged. Fasting also reduced leukotriene B4 from neutrophils. We thus conclude that generate cytotaxins, enzyme, formation an altered fatty composition membrane phospholipids, may be mechanisms for decrease inflammatory symptoms results fasting.
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