Regional differences in the control of lipolysis in human adipose tissue.
作者： Jan Östman , Peter Arner , Peter Engfeldt , Lars Kager
DOI: 10.1016/0026-0495(79)90131-8
关键词:
摘要: Omental fat cells were 30% smaller than those in subcutaneous regions. In omental with a mean diameter of 95 mu, the basal cAMP concentration was 50% lower, but rate glycerol release three times as rapid (epigastric) identical size. Added at maximal effective concentration, noradrenaline increased level and more markedly adipocytes, whereas response to isopropyl similar. Before starvation lipolytic effects noradrenaline, respectively, two regions adipose tissue investigated (femoral hypogastric). The findings well related levels induced by agents. During lipolysis obtained from hypogastric region, decreased these parameters femoral adipocytes. Starvation associated prominent inhibitory effect phenylephrine on isopropyl-noradrenaline-induced tissue. conclusion, differences exist between different their responsiveness which seems balance alpha- beta-adrenergic receptor response.
elsevier.com
sci-hub.se 参考文章(24)
F. A. Gries, M. Berger, M. Neumann, H. Preiss, H. Liebermeister, C. Hesse-Wortmann, K. Jahnke, Effects of norepinephrine, theophylline and dibutyryl cyclic AMP on in vitro lipolysis of human adipose tissue in obesity. Diabetologia. ,vol. 8, pp. 75- 83 ,(1972) , 10.1007/BF01235630
Vincent P. Dole, Hans Meinertz, Microdetermination of long-chain fatty acids in plasma and tissues. Journal of Biological Chemistry. ,vol. 235, pp. 2595- 2599 ,(1960) , 10.1016/S0021-9258(19)76920-8
Jan Kjellberg, Jan Östman, LIPOLYSIS AND GLUCOSE TOLERANCE IN OBESE SUBJECTS DURING PROLONGED STARVATION Acta Medica Scandinavica. ,vol. 190, pp. 191- 198 ,(2009) , 10.1111/J.0954-6820.1971.TB07415.X
M. Hamosh, P. Hamosh, J. A. Bar-Maor, H. Cohen, FATTY-ACID METABOLISM BY HUMAN ADIPOSE TISSUES* Journal of Clinical Investigation. ,vol. 42, pp. 1648- 1652 ,(1963) , 10.1172/JCI104850
A. G. Gilman, A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate Proceedings of the National Academy of Sciences of the United States of America. ,vol. 67, pp. 305- 312 ,(1970) , 10.1073/PNAS.67.1.305
Peter Arner, Relationship between intracellular cyclic AMP and lipolysis in human adipose tissue. Acta Medica Scandinavica. ,vol. 200, pp. 179- 186 ,(2009) , 10.1111/J.0954-6820.1976.TB08217.X
Suad Efendić, Catecholamines and metabolism of human adipose tissue. 3. Comparison between the regulation of lipolysis in omental and subcutaneous adipose tissue. Acta Medica Scandinavica. ,vol. 187, pp. 477- 483 ,(2009) , 10.1111/J.0954-6820.1970.TB02973.X
Peter Arner, Ored Arne, Jan Östman, The effect of local anaesthetic agents on lipolysis by human adipose tissue. Life Sciences. ,vol. 13, pp. 161- 169 ,(1973) , 10.1016/0024-3205(73)90191-4
Lars A. Carlson, Dag Hallberg, Horace Micheli, Quantitative studies on the lipolytic response of human subcutaneous and omental adipose tissue to noradrenaline and theophylline. Acta Medica Scandinavica. ,vol. 185, pp. 465- 469 ,(2009) , 10.1111/J.0954-6820.1969.TB07368.X
H. KATHER, K. ZÖLLIG, B. SIMON, G. SCHLIERF, Human fat cell adenylate cyclase: regional differences in adrenaline responsiveness European Journal of Clinical Investigation. ,vol. 7, pp. 595- 597 ,(1977) , 10.1111/J.1365-2362.1977.TB01657.X