Compact, power-efficient architectures using microvalves and microsensors, for intrathecal, insulin, and other drug delivery systems

摘要: Abstract This paper describes a valve-regulated architecture, for intrathecal, insulin and other drug delivery systems, that offers high performance volume efficiency through the use of micromachined components. Multi-drug protocols can be accommodated by using valve manifold to modulate mix flows from individual reservoirs. A piezoelectrically-actuated silicon microvalve with embedded pressure sensors is used regulate dosing throttling flow mechanically-pressurized reservoir. preliminary prototype system demonstrated two reservoirs, sensors, control circuit board within 130 cm3 metal casing. Different modes programmable have been evaluated mimic clinical applications. Bolus continuous deliveries demonstrated. wide range rates achieved adjusting parameters valves or reservoir springs. The capability compensate changes in has experimentally verified. profiles also detect catheter occlusions disconnects. benefits this architecture compared alternative options are reviewed.