Insulin Micropump with Embedded Pressure Sensors for Failure Detection and Delivery of Accurate Monitoring

摘要: Improved glycemic control with insulin pump therapy in patients type 1 diabetes mellitus has shown gradual reductions nephropathy and retinopathy. More recently, the emerging concept of artificial pancreas, comprising an coupled to a continuous glucose meter algorithm, would become next major breakthrough care. The patient safety efficiency are directly derived from delivery accuracy rapid-acting insulin. For this purpose, specific precision-oriented design micropump been built. device, made stack three silicon wafers, comprises two check valves pumping membrane that is actuated against stop limiters by piezo actuator. Two membranes piezoresistive strain gauges have implemented measure pressure chamber at outlet pump. Their high sensitivity makes possible monitoring tolerance ±5% for each individual stroke 200 nL. capability these sensors monitor priming, reservoir overpressure, emptying, occlusion valve leakage also studied.