Fulminant inflammatory demyelination: long-term course and magnetic resonance imaging findings.

摘要: The course and prognosis of adult patients who recover from acute extensive inflammatory demyelination, variously termed fulminant or Marburg's type multiple sclerosis (MS), is poorly known. We report long-term magnetic resonance imaging (MRI) neuropsychological findings in two developed psychosis a state resembling akinetic mutism, with CT scan evidence cerebral white matter damage. Both ultimately recovered, but were left severe, non-progressive dementia prominent frontal lobe signs unassociated motor impairment. Extensive residual MRI lesions tissue destruction the callosal atrophy visible many years after initial event One single relapsing-remitting episode multifocal neurological deficits several onset, whereas condition remained monophasic other patient during an 8 year follow-up. Our observations suggest that while so-called "fulminant" demyelinating disorders may nowadays survive supportive measures, disorder remain stabilized for following disease onset.