Postantibiotic effect of colistin alone and combined with vancomycin or meropenem against Acinetobacter spp. with well defined resistance mechanisms

作者: Branka Bedenić , Natasa Beader , Karmen Godič-Torkar , Esmina Prahin , Ljiljana Mihaljević

DOI: 10.1179/1973947815Y.0000000062

关键词:

摘要: Previous studies found short postantibiotic effect of colistin on Acinetobacter baumannii. Many have evaluated the potential for synergy between and other antibiotics against A. The aim this study was to determine in vitro (PAE) alone combined with (vancomycin or meropenem) eight carbapenem-non-susceptible spp. strains defined resistance mechanisms. It hypothesised that vancomycin meropenem would prologue PAE since it previously they exert synergism time-kill kinetics chequerboard analysis. After exposure 1 hour exhibited negative ( - 0.07 hour) (OXA-143), (0.2-1.82 hours) (OXA-24, OXA-58, OXA-72, VIM-1+OXA-23, OXA-58+NDM-1, ISAba1/OXA-69) moderate (3.2 hours) OXA-23 positive strain. When vancomycin, (1.7-4 hours) OXA-23, OXA-23+VIM-1, OXA-72 OXA-24 while OXA-143, OXA-58/NDM-1 ISAba1/OXA-69 strains, not possible calculate mean duration because there no regrowth after longer than 5 hours. combination resulted (0.2 hours) (2.4-3.73 hours) OXA-23+VIM-1), long 5 hours (OXA-23) (OXA-58+VIM-1, ISAba1/OXA-69). From clinical point view, prolongation when could provide a rationale modification dosing interval be important optimization treatment regimen minimization drug-induced side effects.

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