Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets

摘要: Two distinct subsets of γδ T cells that produce interleukin 17 (IL-17) (CD27(-) cells) or interferon-γ (IFN-γ) (CD27(+) develop in the mouse thymus, but molecular determinants their functional potential periphery remain unknown. Here we conducted a genome-wide characterization methylation patterns histone H3, along with analysis mRNA encoding transcription factors, to identify regulatory networks peripheral IFN-γ-producing IL-17-producing cell vivo. We found CD27(+) were committed expression Ifng not Il17, whereas CD27(-) displayed permissive chromatin configurations at loci both cytokines and factors differentiated into produced IL-17 IFN-γ tumor microenvironment.