Bacterial Genomes as New Gene Homes: The Genealogy of ORFans in E. coli
作者： Vincent Daubin , Howard Ochman
DOI: 10.1101/GR.2231904
关键词:
摘要: Differences in gene repertoire among bacterial genomes are usually ascribed to loss or lateral transfer from unrelated cellular organisms. However, most bacteria contain large numbers of ORFans, that is, annotated genes restricted a particular genome and possess no known homologs. The uniqueness ORFans within has precluded the use comparative approach examine their function evolution. by identifying sequences unique monophyletic groups at increasing phylogenetic depths, we can make direct comparisons characteristics different ages Escherichia coli genome, establish functional status evolutionary rates. Relative ancestral γ-Proteobacteria those distributed sporadically other prokaryotic species, E. lineage short, A+T rich, evolve quickly. Moreover, encode proteins. Based on these features, not attributable errors annotation, limitations current databases, failure methods for detecting homology. Rather, free-living microorganisms apparently derive bacteriophage occasionally become established assuming roles key functions.
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