Expression of inflammasome-related genes in bladder cancer and their association with cytokeratin 20 messenger RNA

摘要: Abstract Background Inflammation plays a crucial role in different stages of cancer development and has long been associated with various types cancer. Strong associations between dysregulated inflammasome activity human heritable acquired inflammatory diseases highlight the importance this pathway immune response. The is large complex NOD-like receptors called NLRs drives growth progression tumors. aim present study was characterization some NLR genes, NLRP3, NLRP4, NLRP9, NAIP, urine sediment patients bladder Cytokeratin 20 survivin were used as confirmed markers Basic procedures For study, 3 groups subjects considered: harboring cancer, affected by inflammation (CTR1), healthy (CTR0). Total RNA extracted from sediments resulting complementary DNA for amplification real-time polymerase chain reaction. Results stratified according to tumor stage, grade, risk recurrence. Main findings expression cytokeratin always significantly higher when compared that both tumor-free groups. NAIP overexpressed BCa CTR0. Stratification recurrence showed NLRP up-regulations early-stage high-risk comparison CTR0 high-grade CTR1. Principal conclusions These data are relevant demonstrate urothelial carcinoma, making genes potential candidates diagnosis.