The monosialoganglioside GM1 dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats
作者： Ulderico Freo , Mauro Dam , Gilberto Pizzolato , Pietro Pietrini , Timothy T. Soncrant
DOI: 10.1016/0006-8993(93)90317-G
关键词:
摘要: Using the quantitative autoradiographic [14C]2-deoxyglucose technique, regional cerebral metabolic rates for glucose (rCMRglc) were measured in awake male Fischer-344 rats at 1, 2, 3, 4 and 6 h after administration of GM1 30 mg/kg 3 150 or 300 mg/kg. is a natural compound that able to prevent neuron degeneration induced by exposure excitatory amino acids vitro ischemia neurotoxins vivo. mg/kg, dose very effective preventing acid-induced neurotoxicity, produced minimal rCMRglc change over period. reduced rCMRglc, 14 (31%) 29 (64%) brain regions, respectively. Maximal effects occurred hippocampal areas which possess, specific subfields, highest concentrations different acid receptor subtypes. This finding suggests an effect on postreceptor mechanisms common acids.
elsevier.com
sci-hub.se 参考文章(28)
Louis Sokoloff, The Radioactive Deoxyglucose Method Springer, Boston, MA. pp. 1- 82 ,(1982) , 10.1007/978-1-4684-7541-8_1
Stephen D. Skaper, Silvio Mazzari, Guido Vantini, Laura Facci, Gino Toffano, Alberta Leon, Monosialoganglioside GM1 and Modulation of Neuronal Plasticity in CNS Repair Processes Advances in Experimental Medicine and Biology. ,vol. 296, pp. 257- 266 ,(1991) , 10.1007/978-1-4684-8047-4_24
G L Collingridge, R A Lester, Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacological Reviews. ,vol. 41, pp. 143- 210 ,(1989)
Ulderico Freo, Timothy T. Soncrant, Harold W. Holloway, Stanley I. Rapoport, Dose- and time-dependent effects of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a serotonergic 5-HT2 receptor agonist, on local cerebral glucose metabolism in awake rats Brain Research. ,vol. 541, pp. 63- 69 ,(1991) , 10.1016/0006-8993(91)91074-B
L. Facci, A. Leon, S. D. Skaper, Excitatory amino acid neurotoxicity in cultured retinal neurons: involvement of N-methyl-D-aspartate (NMDA) and non-NMDA receptors and effect of ganglioside GM1. Journal of Neuroscience Research. ,vol. 27, pp. 202- 210 ,(1990) , 10.1002/JNR.490270210
Akhlaq A. Farooqui, Lloyd A. Horrocks, Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders Brain Research Reviews. ,vol. 16, pp. 171- 191 ,(1991) , 10.1016/0165-0173(91)90004-R
D. Milani, D. Guidolin, L. Facci, T. Pozzan, M. Buso, A. Leon, S. D. Skaper, Excitatory amino acid-induced alterations of cytoplasmic free Ca2+ individual cerebellar granule neurons: Role in neurotoxicity Journal of Neuroscience Research. ,vol. 28, pp. 434- 441 ,(1991) , 10.1002/JNR.490280317
Daniel W. Clow, Shay J. Lee, Ronald P. Hammer, Competitive (AP7) and non-competitive (MK-801) NMDA receptor antagonists differentially alter glucose utilization in rat cortex. Synapse. ,vol. 7, pp. 260- 268 ,(1991) , 10.1002/SYN.890070403
J.S. Schneider, A. Yuwiler, GM1 ganglioside treatment promotes recovery of striatal dopamine concentrations in the mouse model of MPTP-induced Parkinsonism Experimental Neurology. ,vol. 105, pp. 177- 183 ,(1989) , 10.1016/0014-4886(89)90117-9
Mark L. Mayer, Gary L. Westbrook, The physiology of excitatory amino acids in the vertebrate central nervous system Progress in Neurobiology. ,vol. 28, pp. 197- 276 ,(1987) , 10.1016/0301-0082(87)90011-6