Transcranial Magnetic Stimulation in Autism Spectrum Disorders: Neuropathological Underpinnings and Clinical Correlations.

摘要: Despite growing knowledge about autism spectrum disorder (ASD), research findings have not been translated into curative treatment. At present, most therapeutic interventions provide for symptomatic Outcomes of are judged by subjective endpoints (eg, behavioral assessments) which alongside the highly heterogeneous nature ASD account wide variability in effectiveness treatments. Transcranial magnetic stimulation (TMS) is one first treatments that targets a putative core pathologic feature autism, specifically cortical inhibitory imbalance alters gamma frequency synchronization. Studies show low TMS over dorsolateral prefrontal cortex individuals with decreases power activity and increases difference between responses to target nontarget stimuli. improves executive function skills related self-monitoring behaviors ability apply corrective actions. These improvements manifest themselves as reduction stimulus bound diminished sympathetic arousal. Results become more significant increasing number sessions bear synergism when used along neurofeedback. When applied at frequencies ASD, appears be safe improve multiple patient-oriented outcomes. Future studies should conducted large populations establish predictors outcomes genetic profiling), length persistence benefits, utility booster sessions.