A Systematic Review on the Existing Screening Pathways for Lynch Syndrome Identification.

摘要: Background Lynch Syndrome (LS) is the most common hereditary colon cancer syndrome, accounting for 3–5% of CRC cases, and it associated with development other cancers. Early detection individuals LS relevant, since they can take advantage life-saving intensive care surveillance. The debate regarding best screening policy, however, far from being concluded. This prompted us to conduct a systematic review existing pathways LS. Methods We performed search MEDLINE, ISI Web Science, SCOPUS online databases eligibility criteria inclusion in this required that studies evaluated structured permanent pathway identification carriers. effectiveness was analyzed terms rate. Results identified five eligible studies. All started which three followed universal approach. Concerning laboratory procedures, used immunohistochemistry and/or microsatellite instability testing. If responses tests indicated risk LS, genetic counselling, by geneticist or counselor, mandatory undergo DNA overall rate ranged 0% 5.2%. Conclusions reported different patients. Although current clinical guidelines suggest test all cases identify actual implementation has not been realized. Large-scale programs have potential reduce morbidity mortality CRC, but coordinated efforts educating key stakeholders addressing public needs are still required.