An IncR Plasmid Harbored by a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Strain Possesses Five Tandem Repeats of the blaKPC-2::NTEKPC-Id Fragment.
作者： Ning Dong , Lizhang Liu , Rong Zhang , Kaichao Chen , Miaomiao Xie
DOI: 10.1128/AAC.01775-18
关键词:
摘要: Completed sequences of three plasmids from a carbapenem-resistant hypervirulent Klebsiella pneumoniae isolate, SH9, were obtained. In addition to the pLVPK-like virulence-conferring plasmid (pVir-CR-HvKP_SH9), two multidrug-resistant (pKPC-CR-HvKP4_SH9 and pCTX-M-CR-HvKP4_SH9) predicted originate single pKPC-CR-HvKP4-like multireplicon through homologous recombination. Interestingly, blaKPC-2 gene was detectable in five tandem repeats exhibiting format an NTEKPC-Id-like transposon (IS26-ΔTn3-ISKpn8-blaKPC-2-ΔISKpn6-korC-orf-IS26). The data suggest important role DNA recombination mediating active evolution.
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