KPC-2-encoding plasmids from Escherichia coli and Klebsiella pneumoniae in Taiwan
作者： Ying-Tsong Chen , Jung-Chung Lin , Chang-Phone Fung , Po-Liang Lu , Yin-Ching Chuang
DOI: 10.1093/JAC/DKT409
关键词:
摘要: Results: The CR-EC and CR-KP strains in this study were determined to be ST410 ST11, respectively, by MLST. From CR-EC, we identified a 145 kb conjugative plasmid that carries blaKPC-2, blaCMY-2, blaCTX-M-3 blaTEM-1. is chimera composed of three regions related IncI, IncN RepFIC replicons. CR-KP, an 86.5 plasmid, pKPC-LK30, which carriesblaKPC-2 andblaSHV-11. very similar twoblaKPC-2carrying IncFIIK plasmids, but lacks one the replication origins cannot conjugate. Conclusions: differences cross-species transferability two plasmids can explained genetic between their backbones could have resulted confinedblaKPC-2-carrying outbreak Taiwan. Plasmid pKPC-LKEc firstblaKPC-2-carrying from With relatively high it should closely monitored.
oup.com
nhri.org.tw
oxfordjournals.org
researchgate.net 参考文章(20)
S Saadi, W K Maas, D F Hill, P L Bergquist, Nucleotide sequence analysis of RepFIC, a basic replicon present in IncFI plasmids P307 and F, and its relation to the RepA replicon of IncFII plasmids. Journal of Bacteriology. ,vol. 169, pp. 1836- 1846 ,(1987) , 10.1128/JB.169.5.1836-1846.1987
I. Frasson, E. Lavezzo, E. Franchin, S. Toppo, L. Barzon, A. Cavallaro, S. N. Richter, G. Palu, Antimicrobial Treatment and Containment Measures for an Extremely Drug-Resistant Klebsiella pneumoniae ST101 Isolate Carrying pKPN101-IT, a Novel Fully Sequenced blaKPC-2 Plasmid Journal of Clinical Microbiology. ,vol. 50, pp. 3768- 3772 ,(2012) , 10.1128/JCM.01892-12
Teruya Komano, Akihiro Kubo, Taizo Nisioka, Shufflon: multi-inversion of four contiguous DNA segments of plasmid R64 creates seven different open reading frames Nucleic Acids Research. ,vol. 15, pp. 1165- 1172 ,(1987) , 10.1093/NAR/15.3.1165
R. W. HEDGES, N. DATTA, Plasmids determining I pili constitute a compatibility complex. Microbiology. ,vol. 77, pp. 19- 25 ,(1973) , 10.1099/00221287-77-1-19
Tzu-Wen Huang, Jann-Tay Wang, Tsai-Ling Lauderdale, Tsai-Lien Liao, Jui-Fen Lai, Mei-Chen Tan, Ann-Chi Lin, Ying-Tsong Chen, Shih-Feng Tsai, Shan-Chwen Chang, Complete Sequences of Two Plasmids in a blaNDM-1-Positive Klebsiella oxytoca Isolate from Taiwan Antimicrobial Agents and Chemotherapy. ,vol. 57, pp. 4072- 4076 ,(2013) , 10.1128/AAC.02266-12
Ruth M. Hall, pKM101 is an IS46-promoted deletion of R46 Nucleic Acids Research. ,vol. 15, pp. 5479- 5479 ,(1987) , 10.1093/NAR/15.13.5479
Atsuko Gyohda, Shujuan Zhu, Nobuhisa Furuya, Teruya Komano, Asymmetry of shufflon-specific recombination sites in plasmid R64 inhibits recombination between direct sfx sequences. Journal of Biological Chemistry. ,vol. 281, pp. 20772- 20779 ,(2006) , 10.1074/JBC.M513654200
L. Kristopher Siu, Jung-Chung Lin, Eric Gomez, Robert Eng, Tom Chiang, Virulence and plasmid transferability of KPC Klebsiella pneumoniae at the Veterans Affairs Healthcare System of New Jersey. Microbial Drug Resistance. ,vol. 18, pp. 380- 384 ,(2012) , 10.1089/MDR.2011.0241
Gen-ichi Sampei, Nobuhisa Furuya, Keiko Tachibana, Yasuhiro Saitou, Takuji Suzuki, Kiyoshi Mizobuchi, Teruya Komano, Complete genome sequence of the incompatibility group I1 plasmid R64 Plasmid. ,vol. 64, pp. 92- 103 ,(2010) , 10.1016/J.PLASMID.2010.05.005
I. Chmelnitsky, M. Shklyar, O. Hermesh, S. Navon-Venezia, R. Edgar, Y. Carmeli, Unique genes identified in the epidemic extremely drug-resistant KPC-producing Klebsiella pneumoniae sequence type 258 Journal of Antimicrobial Chemotherapy. ,vol. 68, pp. 74- 83 ,(2013) , 10.1093/JAC/DKS370