Silica nanoparticles inhibit macrophage activity and angiogenesis via VEGFR2-mediated MAPK signaling pathway in zebrafish embryos.
作者： Junchao Duan , Hejing Hu , Lin Feng , Xiaozhe Yang , Zhiwei Sun
DOI: 10.1016/J.CHEMOSPHERE.2017.05.138
关键词:
摘要: The safety evaluation of silica nanoparticles (SiNPs) are getting great attention due to its widely-used in food sciences, chemical industry and biomedicine. However, the adverse effect underlying mechanisms SiNPs on cardiovascular system, especially angiogenesis is still unclear. This study was aimed illuminate possible zebrafish transgenic lines, Tg(fli-1:EGFP) Albino. caused malformations a dose-dependent manner via intravenous microinjection. incidences were observed as: Pericardial edema > Bradycardia > Blood deficiency. area subintestinal vessels (SIVs) significant reduced SiNPs-treated groups, accompanied with weaken expression vascular endothelial cells embryos. Using neutral red staining, quantitative number macrophage declined; whereas inhibition rate elevated way. Furthermore, significantly decreased mRNA activity related gene, migration inhibitory factor (MIF) growth receptor 2 (VEGFR2). protein levels p-Erk1/2 p-p38 MAPK markedly exposed SiNPs. Our results implicate that inhibited downregulation singaling pathway.
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