Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo.

摘要: Pyronaridine is a Mannich base anti-malarial with demonstrated efficacy against drug resistant Plasmodium falciparum, P. vivax, ovale and malariae. However, resistance to pyronaridine can develop quickly when it used alone but be considerably delayed administered artesunate in rodent malaria models. The aim of this study was evaluate the combination falciparum vitro models vivo support its clinical application. showed consistently high levels activity panel six drug-sensitive strains (Geometric Mean IC50 = 2.24 nM, 95% CI 1.20–3.27). In interactions between slight antagonistic trend, compared alone, 3:1 ratio combination, reduced ED90 by ∼15.6-fold pyronaridine-resistant berghei line ∼200-fold an artesunate-resistant berghei. Complete cure rates were achieved doses above or equal 8 mg/kg per day chabaudi AS. These results indicate that had enhanced effect over monotherapy lower daily could obtain curative effect. data suggest should have potential areas multi-drug malaria.