Between-subject and within-subject variations in the pharmacokinetics of ethanol

摘要: 1. Twelve healthy men drank 0.80 g ethanol kg-1 body weight on four occasions spread over several weeks. Ethanol was given as 96% v/v solvent which diluted with orange juice to make a cocktail (20-25% v/v). This drink ingested in exactly 30 min at 08.00 h after an overnight (10 h) fast. 2. Samples of venous blood were obtained timed intervals 0, 10, 20, 30, 45, 60, 90, 120, 150, 180, 240, 300, and 360 the start drinking. The concentrations whole determined by headspace gas chromatography. 3. Summary measures used evaluate concentration-time profiles for each subject. between-subject within-subject components variation pharmacokinetics derived one-way analysis variance (ANOVA). 4. between different subjects dominated total all pharmacokinetic parameters studied except rate disappearance from (ko). For this latter parameter, 42% 58% arose variations between- within-subjects respectively. These results might be important consider when experiments clinical are being planned.