Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding in Portuguese subpopulations and may generalize to broader populations.

摘要: We recently reported genome-wide significant linkage to chromosome 6q for bipolar disorder, in a study of 25 Portuguese families, using the Human Mapping Assay Xba 131 (HMA10K). To explore generalizability this finding, we reanalyzed our SNP data according families’ geographic origin. Specifically, families included 20 from island collection (PIC; 15 Azores Islands and 5 Madeira Islands) continental Portugal. Non-parametric analysis (NPL) was performed as previously described indicated that each these subpopulations showed evidence same region. further address potential findings other populations, have also examined allelic heterozygosity three reference populations (Caucasian, East Asian, African-American). This PIC population is highly correlated Caucasian (R ¼ 0.86) all 6. In contrast more weakly between both Asian 0.37) African-American 0.32) populations. Taken together observations suggest shared genetic liability among disorder on 6q, likely representative Caucasians general. 2005 Wiley-Liss, Inc.