Adenosquamous carcinoma of the pancreas: cytologic features in 14 cases.

摘要: BACKGROUND Adenosquamous carcinoma (ASCa) is a rare subtype of ductal adenocarcinoma the pancreas with what to authors' knowledge are limited cytologic descriptions. In current study, authors describe their experience fine-aspiration biopsy (FNAB) diagnosis ASCa and characterize features in 14 cases. METHODS Fourteen cases were identified from pathology case files. Cytologic material was examined for cellularity, grade, tumor cell necrosis, specific glandular squamous differentiation. RESULTS The 10 females 4 males had an average age 70 years. Nine patients (64%) reported have Stage IV disease at time presentation. All tumors high moderate cellularity. Tumor necrosis noted 12. demonstrated predominantly differentiation keratinization. Seven these nine contained least focal intracellular mucin or honeycombed sheets. Two cytoplasmic vacuoles as only evidence differentiation. Five (36%) glandular. but one five atypical malignant keratinized cells. One lacked keratinization cells dense cytoplasm; confirmed on histology. 13 whom followup known, 12 died (mean, 5.6 months) 1 alive months follow-up. CONCLUSIONS A possible when aspirates show both differentiation, although component often predominates dual may be focal. A purely should raise suspicion metastasis, also represent undersampling ASCa. Cancer (Cancer Cytopathol) 2003;99:372–8. © 2003 American Society.