Prognostic value of imbalanced interhemispheric functional coordination in early therapeutic efficacy in major depressive disorder.
作者： Zhenghua Hou , Xiaopeng Song , Wenhao Jiang , Yingying Yue , Yingying Yin
DOI: 10.1016/J.PSCYCHRESNS.2016.07.011
关键词:
摘要: This study aims to explore the early response of antidepressant therapy by measuring voxel-mirrored homotopic connectivity (VMHC) in major depressive disorder (MDD). Eighty-two MDD patients [n=42 treatment-responsive depression (RD) and n=40 non-responding (NRD)] n=50 normal controls (NC) underwent clinical measures a magnetic resonance imaging scan, VMHC values were calculated. Receiver operating characteristic (ROC) curve analysis was applied determine capability altered distinguish NRD. The NRD showed significantly decreased bilateral precuneus (PCU) inferior temporal gyrus (ITG), increased middle frontal (MFG) caudate nucleus as compared RD. When with NC, exhibited reduced cerebellum anterior lobe, thalamus postcentral gyrus. Moreover, VHMC medial gyrus, precentral Correlation that PCU negatively correlated baseline HAMD score group. ROC indicated combined changes three regional (PCU, ITG MFG) could effectively identify current suggests interhemispheric asynchrony may represents novel neural trait underlying prediction therapeutic outcome MDD.
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