Spontaneous mitochondrial membrane potential change during apoptotic induction by quercetin in K562 and K562/adr cells.
作者： S Kothan , S Dechsupa , G Leger , J L Moretti , J Vergote
DOI: 10.1139/Y04-113
关键词:
摘要: Natural products from plants such as flavonoids are potential drugs to overcome multidrug resistance (MDR) in cancer treatments. However, their modes of action still unclear. In this study, the effects quercetin on mitochondrial membrane (ΔΨm) change well quercetin's ability induce apoptosis and inhibit Pgp-mediated efflux 99mTc-MIBI K562/adr cells were investigated. Quercetin exhibits cytotoxicity against erythroleukemic cells: IC50 11.0 ± 2.0 µmol/L 5.0 0.4 for K562 K562/adr, respectively. induces cell death via both does not 99mTc-MIBI. (10 µmol/L, 3 h) etoposide (100 24 similar levels cells. an increase followed by a decrease |ΔΨm| value depending its concentration. A is associated with percentage early apoptotic It clear...
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