Potential mechanisms of mitochondrial cytochrome‐C release during apoptosis
作者： Anne N. Murphy
DOI: 10.1002/(SICI)1098-2299(199901)46:1<18::AID-DDR4>3.0.CO;2-6
关键词:
摘要: Cytochrome-c release from the intermembrane space of mitochondria to cytoplasm is a critical signaling event during many forms apoptotic cell death. Due widespread involvement apoptosis in pathobiology, this mitochondrial logical target for development new therapeutic approaches numerous diseases. Currently impeding such our lack understanding mechanism by which component electron transport chain occurs response wide variety agents known induce apoptosis. Release induced membrane permeability transition (a change at inner membrane) likely results swelling, consequent rupture outer membrane, and nonspecific contents. An alternative mode may include induction specific membrane. These two mechanisms present distinct molecular targets drug development.
sci-hub.se 参考文章(64)
A. L. Nieminen, A. M. Byrne, B. Herman, J. J. Lemasters, Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species American Journal of Physiology-cell Physiology. ,vol. 272, ,(1997) , 10.1152/AJPCELL.1997.272.4.C1286
J.G. Pastorino, J.W. Snyder, A. Serroni, J.B. Hoek, J.L. Farber, Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. Journal of Biological Chemistry. ,vol. 268, pp. 13791- 13798 ,(1993) , 10.1016/S0021-9258(19)85172-4
George E.N. Kass, Marlene J. Juedes, Sten Orrenius, Cyclosporin A protects hepatocytes against prooxidant-induced cell killing. A study on the role of mitochondrial Ca2+ cycling in cytotoxicity. Biochemical Pharmacology. ,vol. 44, pp. 1995- 2003 ,(1992) , 10.1016/0006-2952(92)90102-O
R. James White, Ian J. Reynolds, Mitochondrial depolarization in glutamate-stimulated neurons : an early signal specific to excitotoxin exposure The Journal of Neuroscience. ,vol. 16, pp. 5688- 5697 ,(1996) , 10.1523/JNEUROSCI.16-18-05688.1996
H. Michael Ellerby, Seamus J. Martin, Lisa M. Ellerby, Shahrouz S. Naiem, Shahrooz Rabizadeh, Guy S. Salvesen, Carlos A. Casiano, Neil R. Cashman, Douglas R. Green, Dale E. Bredesen, Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial Phases The Journal of Neuroscience. ,vol. 17, pp. 6165- 6178 ,(1997) , 10.1523/JNEUROSCI.17-16-06165.1997
AR CROFTS, JB CHAPPELL, CALCIUM ION ACCUMULATION AND VOLUME CHANGES OF ISOLATED LIVER MITOCHONDRIA. REVERSAL OF CALCIUM ION-INDUCED SWELLING. Biochemical Journal. ,vol. 95, pp. 387- 392 ,(1965) , 10.1042/BJ0950387
E J Griffiths, A P Halestrap, Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin Biochemical Journal. ,vol. 274, pp. 611- 614 ,(1991) , 10.1042/BJ2740611
E J Griffiths, A P Halestrap, Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochemical Journal. ,vol. 307, pp. 93- 98 ,(1995) , 10.1042/BJ3070093
A L Nieminen, A K Saylor, S A Tesfai, B Herman, J J Lemasters, Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide Biochemical Journal. ,vol. 307, pp. 99- 106 ,(1995) , 10.1042/BJ3070099
C NAEKYUNG KIM, X WANG, Y HUANG, AM IBRADO, L LIU, G FANG, Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Research. ,vol. 57, pp. 3115- 3120 ,(1997)