Cytochrome C effect on respiration of heart mitochondria: influence of various factors.
作者： Adolfas Toleikis , Sonata Trumbeckaite , Daiva Majiene
DOI: 10.1007/S10540-005-2897-2
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摘要: The effect of exogenous cytochrome c on respiration rate the rat and human heart mitochondria was assessed in situ, using permeabilized fibers. It (i) much more pronounced State 2 4 than 3 with all respiratory substrates (pyruvate+malate, succinate, palmitoyl-CoA+carnitine octanoyl-L-carnitine), (ii) different substrates, (iii) higher after ischemia both metabolic states, particularly case succinate oxidation compared to pyruvate+malate, (iv) highest as a substrate. Similar results were obtained isolated rabbit mitochondria. differences degree stimulation mitochondrial by and, thus, sensitivity test evaluation intactness/injury outer membrane are probably determined role control above-described conditions.
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