Modulation of caspase-3 gene expression and protective effects of garlic and spirulina against CNS neurotoxicity induced by lead exposure in male rats

摘要: Abstract Lead (Pb) is a ubiquitous environmental and industrial pollutant with worldwide health problems. The present study was designed to investigate the neurotoxic effects of Pb in albino rats evaluate ameliorative role garlic as well Spirulina maxima against such toxic effects. Forty adult male were used this investigation (10 rats/group). Group I: served control, II: received lead acetate (100 mg/kg), III: both (100 mg/kg) (600 mg/kg) IV: spirulina (500 mg/kg) daily by oral gavage for one month. Exposure adversely affected measured acetyl cholinesterase enzyme activity, oxidative stress lipid peroxidation parameters caspase-3 gene expression brain tissue (cerebrum cerebellum). Light electron microscopical examination cerebrum cerebellum showed various lesions after exposure which confirmed immunohistochemistry. On other hand, administration concomitantly ameliorated most undesirable It could be concluded that, adverse induced acetate, markedly co-treatment S. more than garlic.