Severity of osteoporosis: what is the impact of co-morbidities?

摘要: The co-morbidity profile varies widely across postmenopausal women with osteoporosis, and comorbidities often adversely affect the management of osteoporosis. There is a need for detailed information on co-morbidities that may course osteoporosis by increasing risk subsequent fractures or inducing multiple fractures. We consequently reviewed literature most common in adults older than 50 years age, special attention to published meta-analyses. found severity was increased not only conventional factors, but also number conditions including inflammatory bowel joint diseases without glucocorticoid therapy, breast cancer prostate treated chemotherapy hormone diabetes (chiefly type 1), celiac disease. Studies suggest an adverse impact moderate renal failure depression, although their methodological weaknesses preclude definitive conclusions. In practice, these should be taken into account when evaluating fracture making treatment decisions.