Modern Soft Tissue Pathology: PRIMARY SOFT TISSUE TUMORS WITH EPITHELIAL DIFFERENTIATION

摘要: Epithelial differentiation is often easily detected histologically and almost always highlighted with immunohistochemical markers (i.e., keratins, epithelial membrane antigen [EMA], others). Mesothelial proliferations tumors are discussed in Chapter 28, Merkel cell carcinoma metastatic carcinomas 29. Some other nonepithelial cells also can express keratins markers. Examples of normal varyingly keratin-positive mesenchymal include endothelial smooth muscle some myofibroblasts. Many tumors, such as melanomas many sarcomas, occasionally keratin positive. These the appropriate chapters. Synovial sarcoma epithelioid soft tissue unknown histogenesis. not thought to be closely related. Mixed related skin adnexal chordoma, a tumor mimicking features notochord cells, reviewed here. SYNOVIAL SARCOMA A synovial specific dual differentiation. The lining its association synovia, if any, only incidental. name based on historical reasons, because component biphasic was once replicate slits. typical t(X;18) translocation SS18-SSX gene fusion useful diagnostic marker. Demographics Sarcoma sarcomas relatively common constituting from 7% 10% all sarcomas. This typically presents young adults, median age approximately 30 years mild male predominance.