Rapid determination of nine parabens and seven other environmental phenols in urine samples of German children and adults

摘要: We developed a fast, selective and sensitive on-line LC/LC-MS/MS method for the simultaneous determination of nine parabens seven environmental phenols in urine. Parabens are widely used as antimicrobial preservatives. Bisphenol A, triclosan, triclocarban, 2-phenylphenol, benzophenones inter alia disinfectants, sunscreens polymers. Some these substances suspected endocrine disruptors. Limits quantification analytical quality criteria fully met needs determining exposure levels occurring general population. analyzed 157 spot urine samples from German population (59 females, 39 males 59 children). For parabens, we found methyl, ethyl n-propyl paraben with high detection rates (77-98%), followed by n-butyl (36%), iso-butyl (17%), iso-propyl (3%) benzyl (3%). detected no pentyl heptyl paraben. Urinary concentrations were highest methyl (median 24.5 μg/L; 95th percentile 379 μg/L) (1.4 35.2 (1.2 68.1 μg/L). Other BPA (95%), triclosan (45%) benzophenone 1 3 (26%). most parabens/environmental higher urinary females than or children, probably due to differences (personal care) product use. However, (in mg/L range) also observed children. Exposure above is worldwide. Differences between countries do seem exist might be caused different compositions use habits. Human metabolism data urgently needed extrapolate biomarker doses actually taken up.