Hijacking of basic research: The case of synthetic cannabinoids

作者: Jenny Wiley , Julie Marusich , J.W. Huffman , R.L. Balster , Brian Thomas

DOI: 10.3768/RTIPRESS.2011.OP.0007.1111

关键词:

摘要: Gathering and communicating knowledge are important aspects of the scientific endeavor. Yet presentation data in public forums such as meetings publications makes it available not only to scientists, but also others who may have different ideas about how use research findings. A recent example this type hijacking is introduction synthetic cannabinoids that sprayed on herbal products subsequently smoked for their marijuana-like intoxicating properties. Originally developed legitimate purpose furthering understanding cannabinoid system, these being abused worldwide, creating issues regulatory law enforcement agencies struggling keep up with growing number compounds various structural motifs. Basic clinical scientists need provide advice now facilitate decision-making health threats posed by emerging problem.

参考文章(39)
Mel McGiobuin, Not for human consumption. ,(2010)
Brady K Atwood, John Huffman, Alex Straiker, Ken Mackie, JWH018, a common constituent of ‘Spice’ herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist British Journal of Pharmacology. ,vol. 160, pp. 585- 593 ,(2010) , 10.1111/J.1476-5381.2009.00582.X
A C Howlett, L S Melvin, W A Devane, F A Dysarz, M R Johnson, Determination and characterization of a cannabinoid receptor in rat brain. Molecular Pharmacology. ,vol. 34, pp. 605- 613 ,(1988)
David Russell, Charles R. Ensor, Barbara Bohner, Graham Chen, THE PHARMACOLOGY OF 1-(1-PHENYLCYCLOHEXYL) PIPERIDINE-HCL Journal of Pharmacology and Experimental Therapeutics. ,vol. 127, pp. 241- 250 ,(1959)
Robert L. Balster, David R. Compton, Lisa H. Gold, Susan J. Ward, Billy R. Martin, Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol. Journal of Pharmacology and Experimental Therapeutics. ,vol. 263, pp. 1118- 1126 ,(1992)
Vincent M. Showalter, Mary E. Abood, Graeme Griffin, Peter J. Atkinson, Billy R. Martin, Evaluation of Cannabinoid Receptor Agonists and Antagonists Using the Guanosine-5′-O-(3-[35S]thio)-triphosphate Binding Assay in Rat Cerebellar Membranes Journal of Pharmacology and Experimental Therapeutics. ,vol. 285, pp. 553- 560 ,(1998)
V M Showalter, M E Abood, D R Compton, B R Martin, Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. Journal of Pharmacology and Experimental Therapeutics. ,vol. 278, pp. 989- 999 ,(1996)
J. Huffman, The search for selective ligands for the CB2 receptor. Current Pharmaceutical Design. ,vol. 6, pp. 1323- 1337 ,(2000) , 10.2174/1381612003399347
Helge Müller, Wolfgang Sperling, Martin Köhrmann, Hagen B. Huttner, Johannes Kornhuber, Juan-Manuel Maler, The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes Schizophrenia Research. ,vol. 118, pp. 309- 310 ,(2010) , 10.1016/J.SCHRES.2009.12.001
Jenny L. Wiley, John W. Huffman, Robert L. Balster, Billy R. Martin, Pharmacological specificity of the discriminative stimulus effects of Δ9-tetrahydrocannabinol in rhesus monkeys Drug and Alcohol Dependence. ,vol. 40, pp. 81- 86 ,(1995) , 10.1016/0376-8716(95)01193-5