A comprehensive study of the enantioseparation of chiral drugs by cyclodextrin using capillary electrophoresis combined with theoretical approaches.
作者： Libo Li , Xia Li , Quan Luo , Tianyan You
DOI: 10.1016/J.TALANTA.2015.04.039
关键词:
摘要: Four chiral drugs were enantioseparated by native beta-cyclodextrin (β-CD) and negatively charged carboxymethyl-beta-cyclodextrin (CM-β-CD) using capillary electrophoresis coupled with electrochemiluminescence detection (CE-ECL). Using 50 mM pH 5.5 Tris-H3PO4 10 CM-β-CD as a running buffer, high resolution efficiency could be obtained. With the help of isothermal titration calorimetry (ITC), nuclear magnetic resonance (NMR) molecular modeling, recognition mechanism was comprehensively investigated. Thermodynamic parameters data from ITC revealed that exhibited stronger binding affinity analytes than β-CD, driving forces responsible for mainly electrostatic interactions between positively analytes. In addition, both macroscopic microscopic point view, results NMR modeling investigation adequately confirm conclusion comparing stereochemical structures complexes. Combination ITC, techniques not only can assist CE to investigate discrimination mechanism, but also predict guide enantioseparation conversely.
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