Functional implications of assigned, assumed and assembled PKC structures

摘要: The empirical derivation of PKC (protein kinase C) domain structures and those modelled by homology or imputed from protein behaviour have been extraordinarily valuable both in the elucidation pathway mechanisms general lessons that extrapolate to other signalling pathways. For family members, there are many domain/subdomain models, covering all known domains, variably present this serine/threonine kinases (C1, C2, PB1, HR1, domains). In addition these structures, a limited number complexes defined, including structure PKCe V3–14-3-3 complex. context structure-driven insights into pathways, several broadly applicable principles relevant operation intervention These an impact unexpected ways, regulation membrane targeting, through strategies for pharmacological intervention, biomarkers.