Validation of self-reported smoking status by simultaneous measurement of carbon monoxide and salivary thiocyanate.

摘要: Abstract Objective. The objective of this study was to determine the validity tobacco questionnaires when using as gold standard either a single biomarker or combination two biomarkers. Methods. methods were self-reported smoking compared with salivary thiocyanate and expired carbon monoxide in 1996, population-based, Swiss survey 552 men 565 women. Results. Sensitivity relative thiocynate alone low (38.2% for ≥ 100 mg/L, 56.4% 150 mg/L 62.6% 9 ppm). When defining true positive smokers people high concentration both monoxide, overall, sensitivity 88.6% specificity 87.2%. In women, increased from 85 89% removing subjects exposed passive smoking. excluding heavy smokers, decreased 63% 71% Older women had tendency misreport Conclusions. This comparison questionnaire data simultaneous measurement indicates that valid responses can be obtained self-reported, current population-based surveys. However, underestimated if (of exposure smoke) is levels thiocyanate.