Synthetic peptides derived from human antimicrobial peptide ubiquicidin accumulate at sites of infections and eradicate (multi-drug resistant) Staphylococcus aureus in mice.
作者： Carlo P.J.M. Brouwer , Sylvia J.P. Bogaards , Marty Wulferink , Markwin P. Velders , Mick M. Welling
DOI: 10.1016/J.PEPTIDES.2006.05.022
关键词:
摘要: The presence and antimicrobial activity of peptides (AMPs) has been widely recognized as an evolutionary preserved part the innate immune system. Based on evidence in animal models humans, AMPs are now positioned novel anti-infective agents. current study aimed to evaluate potential ubiquicidin small synthetic fragments thereof towards methicillin resistant Staphylococcus aureus (MRSA), a high priority target for antibiotics. In vitro killing MRSA by derived from alpha-helix or beta-sheet domains human cationic peptide (UBI 1-59), allowed selection possible treatment infections. strongest antibacterial was observed entire UBI 1-59 comprising amino acids 31-38. availability, chemical synthesis opportunities, size these peptides, combined with their strong make compounds promising candidates therapy detection infections man.
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