摘要: Age-related bone loss is in large part the consequence of senescence mechanisms that impact cell number and function. In recent years, progress has been made understanding molecular underlying contributes to alteration skeletal integrity during aging. These can be classified as intrinsic processes, alterations endogenous anabolic factors, changes local support. Intrinsic cause cellular dysfunctions are not tissue specific include telomere shortening, accumulation oxidative damage, impaired DNA repair, altered epigenetic regulating gene transcription. Aging more relevant microenvironment expression signaling growth factors intercellular communications. This review provides an integrated overview current concepts interacting aging how they could targeted reduce negative skeleton. © 2014 American Society for Bone Mineral Research.
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