作者: Pierre J. Marie
DOI: 10.1007/S00018-014-1801-2
关键词: Protein degradation 、 Biology 、 Primary bone 、 Cancer research 、 Epigenetics 、 Osteoblast 、 Pathology 、 Wnt signaling pathway 、 Cellular differentiation 、 Osteosarcoma 、 Osteoporosis
摘要: Several metabolic, genetic and oncogenic bone diseases are characterized by defective or excessive formation. These abnormalities caused dysfunctions in the commitment, differentiation survival of cells osteoblast lineage. During recent years, significant advances have been made our understanding cellular molecular mechanisms underlying osteoporosis, skeletal dysplasias primary tumors. This led to suggest novel therapeutic approaches correct these such as modulation WNT signaling, pharmacological proteasome-mediated protein degradation, induction osteoprogenitor cell differentiation, repression cancer proliferation manipulation epigenetic mechanisms. article reviews current major inducing osteoblastic age-related loss, tumors, discusses emerging strategies counteract disorders