Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies

作者: Pierre J. Marie

DOI: 10.1007/S00018-014-1801-2

关键词: Protein degradationBiologyPrimary boneCancer researchEpigeneticsOsteoblastPathologyWnt signaling pathwayCellular differentiationOsteosarcomaOsteoporosis

摘要: Several metabolic, genetic and oncogenic bone diseases are characterized by defective or excessive formation. These abnormalities caused dysfunctions in the commitment, differentiation survival of cells osteoblast lineage. During recent years, significant advances have been made our understanding cellular molecular mechanisms underlying osteoporosis, skeletal dysplasias primary tumors. This led to suggest novel therapeutic approaches correct these such as modulation WNT signaling, pharmacological proteasome-mediated protein degradation, induction osteoprogenitor cell differentiation, repression cancer proliferation manipulation epigenetic mechanisms. article reviews current major inducing osteoblastic age-related loss, tumors, discusses emerging strategies counteract disorders

参考文章(207)
Ashley N. Rettew, Patrick J. Getty, Edward M. Greenfield, Receptor Tyrosine Kinases in Osteosarcoma: Not Just the Usual Suspects Advances in Experimental Medicine and Biology. ,vol. 804, pp. 47- 66 ,(2014) , 10.1007/978-3-319-04843-7_3
Mara Riminucci, Pamela Gehron Robey, Paolo Bianco, The pathology of fibrous dysplasia and the McCune-Albright syndrome. Pediatric endocrinology reviews. pp. 401- ,(2007)
Masanobu Kawai, Clifford J. Rosen, The Insulin-Like Growth Factor System in Bone Endocrinology and Metabolism Clinics of North America. ,vol. 41, pp. 323- 333 ,(2012) , 10.1016/J.ECL.2012.04.013
Jane E. Aubin, Regulation of osteoblast formation and function. Reviews in Endocrine & Metabolic Disorders. ,vol. 2, pp. 81- 94 ,(2001) , 10.1023/A:1010011209064
Claire Magnon, Daniel Lucas, Paul S. Frenette, Trafficking of Stem Cells Methods in Molecular Biology. ,vol. 750, pp. 3- 24 ,(2011) , 10.1007/978-1-61779-145-1_1
Pierre J. Marie, Cellular and molecular basis of fibrous dysplasia. Histology and Histopathology. ,vol. 16, pp. 981- 988 ,(2001) , 10.14670/HH-16.981
P. Chanson, A. Lomri, P. J. Marie, C. de Pollak, Increased proliferation of osteoblastic cells expressing the activating Gs alpha mutation in monostotic and polyostotic fibrous dysplasia. American Journal of Pathology. ,vol. 150, pp. 1059- 1069 ,(1997)
Romosozumab in postmenopausal women with osteopenia. The New England Journal of Medicine. ,vol. 370, pp. 1664- 1664 ,(2014) , 10.1056/NEJMC1402396
Pierre J. Marie, Karim Kaabeche, Hind Guenou, Roles of FGFR2 and twist in human craniosynostosis: insights from genetic mutations in cranial osteoblasts. Frontiers of oral biology. ,vol. 12, pp. 144- 159 ,(2008) , 10.1159/000115036