Prospective MEG Biomarkers in ASD: Pre-Clinical Evidence and Clinical Promise of Electrophysiological Signatures

摘要: Autism spectrum disorders (ASD) are characterized by social impairments and restricted/stereotyped behaviors currently affect an estimated 1 in 68 children aged 8 years old. While there has been substantial recent focus on ASD research, both the biological pathology and, perhaps consequently, a fully effective treatment have yet to be realized. What remained throughout is hypothesis that neurobiological underpinnings observation phenotypic expression likely underlying etiology highly heterogeneous. Given neurodevelopmental basis of ASD, biologically based marker (biomarker) could prove useful not only for diagnostic prognostic purposes, but also stratification response indices pharmaceutical development. In this review, we examine current state field MEG-related biomarkers ASD. We describe several potential (middle latency delays [M50/M100], mismatch negativity latency, gamma-band oscillatory activity), investigate their relation symptomology, core domains dysfunction (e.g., language impairment), putative underpinnings.