Xenobiotics: Interaction with the Intestinal Microflora

作者: Kun Lu , Ridwan Mahbub , James G. Fox

DOI: 10.1093/ILAR/ILV018

关键词:

摘要: The human body is host to 100 trillion gut microbes, approximately 10-times more than all cells. It estimated that the 500-1000 species residing in encode 150-fold unique genes genome. microbiota has important functions metabolic processing, such as energy production, immune cell development, food digestion, and epithelial homeostasis. been increasingly recognized a dysregulated microbiome contributes significant way variety of diseases, including diabetes, obesity, cardiovascular allergies, inflammatory bowel disease. In particular, accumulating evidence indicates functional interactions between xenobiotics play role mediating chemical toxicity causing or exacerbating This review summarizes emerging illustrates how can affect structure, create changes microbiome, become biotransformed by microbiome.

参考文章(113)
Steven J. Siegel, Gregory C. Carlson, Matthew Ku, Timothy P.L. Roberts, Russell G. Port, Ayesha R. Anwar, Prospective MEG Biomarkers in ASD: Pre-Clinical Evidence and Clinical Promise of Electrophysiological Signatures Yale Journal of Biology and Medicine. ,vol. 88, pp. 25- 36 ,(2015)
Jaejoon Jung, Aram Heo, Yong Woo Park, Ye Ji Kim, Hyelim Koh, Woojun Park, Gut microbiota of Tenebrio molitor and their response to environmental change. Journal of Microbiology and Biotechnology. ,vol. 24, pp. 888- 897 ,(2014) , 10.4014/JMB.1405.05016
Kun Lu, Ridwan Mahbub, Peter Hans Cable, Hongyu Ru, Nicola MA Parry, Wanda M Bodnar, John S Wishnok, Miroslav Styblo, James A Swenberg, James G Fox, Steven R Tannenbaum, None, Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism Chemical Research in Toxicology. ,vol. 27, pp. 172- 174 ,(2014) , 10.1021/TX400454Z
Balakrishnan S Ramakrishna, Role of the gut microbiota in human nutrition and metabolism Journal of Gastroenterology and Hepatology. ,vol. 28, pp. 9- 17 ,(2013) , 10.1111/JGH.12294
Dieter Koch-Weser, J. de la Huerga, Hans Popper, Effect of choline supplements on fatty metamorphosis and liver cell damage in choline and protein deficiency. Journal of Nutrition. ,vol. 49, pp. 443- 452 ,(1953) , 10.1093/JN/49.3.443
Emeran A. Mayer, David Padua, Kirsten Tillisch, Altered brain-gut axis in autism: Comorbidity or causative mechanisms? BioEssays. ,vol. 36, pp. 933- 939 ,(2014) , 10.1002/BIES.201400075
Tadashi Watabe, Atsushi Kato, Kenichiro Ogura, Hiroaki Takubo, Haruhiro Okuda, A Possible Mechanism of Eighteen Patient Deaths Caused by Interactions of Sorivudine, a New Antiviral Drug, with Oral 5-Fluorouracil Prodrugs Journal of Pharmacology and Experimental Therapeutics. ,vol. 287, pp. 791- 799 ,(1998)
TAKEMI KINOUCHI, KEIKO KATAOKA, KOICHI MIYANISHI, SHIGERU AKIMOTO, YOSHINARI OHNISHI, Role of intestinal microflora in metabolism of glutathione conjugates of 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide. Tohoku Journal of Experimental Medicine. ,vol. 168, pp. 119- 122 ,(1992) , 10.1620/TJEM.168.119
Stephanie H. Chan, Victor C. Van Hee, Silas Bergen, Adam A. Szpiro, Lisa A. DeRoo, Stephanie J. London, Julian D. Marshall, Joel D. Kaufman, Dale P. Sandler, Long-Term Air Pollution Exposure and Blood Pressure in the Sister Study. Environmental Health Perspectives. ,vol. 123, pp. 951- 958 ,(2015) , 10.1289/EHP.1408125
John Headley, Willy Verstraete, Steven Siciliano, Tom Van de Wiele, Lynn Vanhaecke, Charlotte Boeckaert, Kerry Peru, Human Colon Microbiota Transform Polycyclic Aromatic Hydrocarbons to Estrogenic Metabolites Environmental Health Perspectives. ,vol. 113, pp. 6- 10 ,(2004) , 10.1289/EHP.7259